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. Author manuscript; available in PMC: 2021 Feb 8.
Published in final edited form as: Am J Psychiatry. 2020 Jan 7;177(3):223–232. doi: 10.1176/appi.ajp.2019.19030256

TABLE 3.

Polygenic risk scores generated from the Million Veteran Program genome-wide association study (GWAS) of GAD-2 anxiety trait and predicting into other relevant GWAS summary statisticsa

Trait (Reference Number) GWAS p Threshold SNPs Tested (N) r2 p
PGC depression (1) 0.145 89,152 0.002445 2.05E–94
PGC PTSD (35) 0.075 58,854 0.002330 4.23E–12
ANGST anxiety (8) 0.415 83,033 0.004884 3.66E–20
iPSYCH anxiety (9) 0.130 79,974 0.004853 6.68E–36
a

ANGST=Anxiety Neuro Genetics Study; GAD-2=Generalized Anxiety Disorder 2-item scale; iPSYCH=Initiative for Integrative Psychiatric Research; PGC=Psychiatric Genomics Consortium; PTSD=posttraumatic stress disorder. The best-fitting polygenic risk score (PRS) is shown for each trait. The first data column contains the threshold used for the best-fitting PRS. The second column indicates the number of SNPs tested in the best-fitting PRS. The r2 is the variance explained by the GAD-2 SNPs at the p value threshold used to create the given PRS.