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. 2021 Feb 2;12(3):185–198. doi: 10.18632/oncotarget.27879

Figure 5. The effect of hCEC-Exo-214 in combination with anti-cancer drugs on P-gp and SF3B3 in HCC cells.

Figure 5

(A and B) Representative Western blot images and quantitative data of protein levels of P-gp (A) and SF3B3 (B) in HepG2 and Hep3B cells 2 days after treatment. Blot images of sorafenib treatment set were combined with no drug and oxaliplatin treatment set. Western blot band intensity was quantified by using ImageJ with normalization to GAPDH. Values are expressed in mean ± SEM. N = 3. (C) Dual-luciferase activity assay. Putative miR-214-3p target sequence of SF3B3 3′-UTR region were listed. WT: wildtype. mut: mutant. Assay was performed in HepG2 cells. NC: negative control. Values are normalized and are presented in mean ± SEM. N = 3 individual experiments.