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. Author manuscript; available in PMC: 2021 Feb 8.
Published in final edited form as: Invert Neurosci. 2019 Sep 5;19(4):11. doi: 10.1007/s10158-019-0231-0

Fig. 5.

Fig. 5

Effects of selected nAChR antagonists on the Aca-ACR-16. Sample trace and bar chart showing inhibition (mean ± SEM, %; n = 6) of acetylcholine-mediated currents by selected antagonists (10 μM). d-tubocurarine (d-TC), mecamylamine (mec) and dihydro-β-erythroidine (DHβE) produced almost complete inhibition of ACh mediated responses. Derquantel (der) and hexamethonium (hexa) produced moderate blockade of Aca-ACR-16 mediated ACh responses and α-BTX was the least potent antagonist. The rank-order potency series for nAChR antagonists is as follows: d-TC (100.0 ± 0.1) ≈ mec (98.8 ± 0.6) ≈ DHβE (98.8 ± 0.4) > der (72.0 ± 5.6) > hexa (52.2 ± 5.6) ≈ α-BTX (49.3 ± 5.2). Inset: magnified view of current trace showing predicted acetylcholine response in the absence of DHβE (dotted line) and inhibition of acetylcholine-mediated response in the presence of DHβE (highlighted in blue)