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. Author manuscript; available in PMC: 2021 Feb 8.
Published in final edited form as: Cell Rep. 2021 Jan 26;34(4):108683. doi: 10.1016/j.celrep.2020.108683

Figure 3. PAC recapitulates the properties of the endogenous endosomal Cl− channel.

Figure 3.

(A–C) PAC-mediated acid-sensitive currents monitored by voltage-ramp (left) and voltage-step (right) protocols in PAC KO endosomes: (A) (pH 5.5) 150 mM luminal and cytosolic Cl−; (B) (pH 5.5) 1 mM luminal and 150 mM cytosolic Cl−; and (C) (pH 7.2) 150 mM luminal and cytosolic Cl−. (D) Current amplitudes of (A)–(C) at +100 mV. Error bars represent mean ± SEM.