Table 3.
Urinary system disease risks among ovarian cancer survivors compared to a general population of women, by years since cancer diagnosis
| 1 to <5 years after cancer diagnosis | 5+ years after cancer diagnosis | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Ovarian cancer survivors | General population | Ovarian cancer survivors | General population | |||||||
| N | % | N | % | HR (95% CI)a | N | % | N | % | HR (95% CI)a | |
| Diseases of the urinary system | 245 | 34.6% | 511 | 19.3% | 2.53 (2.12, 3.01) | 91 | 35.8% | 207 | 27.1% | 1.30 (0.97, 1.73) |
| Nephritis; nephrosis; renal sclerosis | 17 | 1.4% | 24 | 0.5% | 4.54 (1.95, 10.58) | 11 | 2.0% | 30 | 1.5% | 1.20 (0.51, 2.81) |
| Acute and unspecified renal failure | 77 | 6.4% | 117 | 2.5% | 4.23 (2.97, 6.02) | 49 | 9.2% | 104 | 5.3% | 2.35 (1.57, 3.52) |
| Acute renal failure | 71 | 5.9% | 107 | 2.2% | 4.26 (2.94, 6.16) | 46 | 8.6% | 94 | 4.7% | 2.42 (1.59, 3.69) |
| Unspecified renal failure | 21 | 1.7% | 34 | 0.7% | 4.94 (2.46, 9.91) | 10 | 1.8% | 38 | 1.8% | 1.27 (0.54, 2.97) |
| Chronic kidney disease | 36 | 2.9% | 95 | 1.9% | 2.45 (1.54, 3.90) | 36 | 6.6% | 106 | 5.2% | 2.24 (1.40, 3.57) |
| Urinary tract infections | 160 | 18.5% | 312 | 10.6% | 2.39 (1.93, 2.95) | 74 | 21.0% | 199 | 18.7% | 1.33 (0.99, 1.78) |
| Infections of kidney | 28 | 2.3% | 46 | 1.0% | 2.95 (1.75, 4.99) | 9 | 1.7% | 59 | 3.0% | 0.64 (0.32, 1.29)* |
| Cystitis and urethritis | 30 | 2.5% | 78 | 1.6% | 2.26 (1.41, 3.63) | 16 | 3.0% | 36 | 1.8% | 1.53 (0.74, 3.16) |
| Urinary tract infection; site not specified | 155 | 17.3% | 302 | 9.8% | 2.46 (1.98, 3.05) | 69 | 18.8% | 195 | 17.3% | 1.28 (0.95, 1.74) |
| Calculus of urinary tract | 35 | 2.9% | 82 | 1.7% | 2.01 (1.30, 3.10) | 24 | 4.6% | 43 | 2.3% | 2.23 (1.28, 3.89) |
| Calculus of kidney | 27 | 2.2% | 46 | 1.0% | 2.80 (1.63, 4.82) | 18 | 3.4% | 30 | 1.5% | 2.28 (1.18, 4.43) |
| Calculus of ureter | 9 | 0.7% | 34 | 0.7% | 1.21 (0.55, 2.62) | 7 | 1.3% | 27 | 1.3% | 1.23 (0.50, 3.05) |
| Other and unspecified urinary calculus | 13 | 1.1% | 36 | 0.7% | 1.69 (0.86, 3.32) | 6 | 1.1% | 20 | 1.0% | 0.83 (0.30, 2.33) |
| Other diseases of kidney and ureters | 148 | 15.6% | 126 | 3.4% | 2.19 (1.88, 2.55)* | 56 | 14.0% | 93 | 6.4% | 2.76 (1.90, 4.01) |
| Hydronephrosis | 97 | 8.3% | 16 | 0.3% | 35.94 (18.78, 68.80) | 25 | 5.0% | 15 | 0.8% | 9.10 (4.29, 19.33) |
| Other and unspecified diseases of kidney and ureters | 134 | 13.7% | 121 | 3.2% | 5.95 (4.65, 7.63)* | 50 | 12.0% | 87 | 5.7% | 2.62 (1.76, 3.88) |
| Other diseases of bladder and urethra | 36 | 3.0% | 63 | 1.3% | 3.15 (1.98, 5.02) | 25 | 4.8% | 51 | 2.6% | 2.32 (1.33, 4.04) |
| Bladder neck obstruction | 2 | 0.2% | 1 | 0.0% | --- | 1 | 0.2% | 0 | 0.0% | --- |
| Other and unspecified diseases of bladder and urethra | 34 | 2.8% | 63 | 1.3% | 2.75 (1.81, 4.18)* | 24 | 4.6% | 51 | 2.6% | 2.29 (1.31, 3.99) |
| Genitourinary symptoms and ill-defined conditions | 135 | 15.5% | 272 | 8.8% | 2.35 (1.87, 2.96) | 69 | 19.3% | 176 | 15.6% | 1.50 (1.09, 2.07) |
| Hematuria | 39 | 3.3% | 92 | 2.0% | 1.87 (1.25, 2.78) | 28 | 5.5% | 69 | 3.8% | 1.43 (0.88, 2.33) |
| Retention of urine | 24 | 2.0% | 22 | 0.5% | 5.74 (2.98, 11.06) | 11 | 2.0% | 31 | 1.5% | 1.62 (0.74, 3.55) |
| Other and unspecified genitourinary symptoms | 132 | 14.1% | 261 | 7.6% | 2.72 (2.15, 3.45) | 72 | 18.5% | 171 | 13.4% | 1.72 (1.25, 2.37) |
Abbreviation: HR, hazard ratio; CI, confident interval.
a.
Models adjusted for matching factors, race, baseline BMI, baseline Charlson Comorbidity Index.
*
Proportional hazards assumption not met; flexible model used.