Table 4.
Genital organ disease risks among ovarian cancer survivors in comparison to the general population of women, by years since cancer diagnosis
| 1 to <5 years after cancer diagnosis | 5+ years after cancer diagnosis | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Ovarian cancer survivors | General population | Ovarian cancer survivors | General population | |||||||
| N | % | N | % | HR (95% CI)a | N | % | N | % | HR (95% CI)a | |
| Diseases of female genital organs | 156 | 22.1% | 433 | 16.4% | 1.88 (1.57, 2.27)* | 26 | 14.6% | 93 | 17.4% | 0.96 (0.60, 1.54) |
| Inflammatory diseases of female pelvic organs | 57 | 5.9% | 78 | 2.2% | 3.58 (2.45, 5.24) | 19 | 5.1% | 45 | 3.5% | 1.52 (0.85, 2.72) |
| Pelvic peritoneal adhesions | 33 | 2.9% | 12 | 0.3% | 16.59 (7.00, 39.34) | 9 | 1.9% | 5 | 0.3% | 8.88 (1.88, 41.91) |
| Cervicitis and endocervicitis | 3 | 0.3% | 23 | 0.5% | 0.62 (0.18, 2.11) | 2 | 0.4% | 8 | 0.4% | 1.11 (0.21, 5.81) |
| Pelvic inflammatory disease | 2 | 0.2% | 1 | 0.0% | 6.43 (0.15, 271.97) | --- | --- | --- | --- | --- |
| Other inflammatory diseases of female pelvic organs | 37 | 3.2% | 64 | 1.4% | 2.86 (1.83, 4.46) | 22 | 4.4% | 53 | 2.9% | 1.80 (1.06, 3.07) |
| Endometriosis | 4 | 0.4% | 26 | 0.6% | 0.88 (0.29, 2.64) | 4 | 0.8% | 18 | 1.1% | 0.95 (0.30, 3.05) |
| Menstrual disordersb | 6 | 2.1% | 92 | 9.3% | 0.25 (0.11, 0.59) | 12 | 2.6% | 52 | 4.0% | 0.71 (0.38, 1.34)* |
| Ovarian cyst | 19 | 1.8% | 51 | 1.3% | 1.85 (1.09, 3.13)* | 7 | 1.6% | 17 | 1.1% | 1.29 (0.49, 3.41) |
| Menopausal disorders | 88 | 8.8% | 240 | 6.9% | 1.61 (1.24, 2.10) | 38 | 9.8% | 139 | 11.5% | 1.06 (0.72, 1.58) |
| Female infertility | 2 | 0.2% | 10 | 0.2% | 0.64 (0.11, 3.76) | 3 | 0.5% | 2 | 0.1% | 7.71 (0.84, 70.89) |
| Other female genital disorders | 81 | 12.7% | 149 | 7.1% | 2.38 (1.76, 3.21) | 20 | 8.7% | 66 | 10.0% | 0.97 (0.59, 1.61)* |
| Female genital pain and other symptoms | 62 | 6.9% | 128 | 3.9% | 2.32 (1.71, 3.15)* | 25 | 6.8% | 72 | 5.9% | 1.37 (0.85, 2.21) |
| Other and unspecified female genital disorders | 61 | 7.5% | 117 | 4.2% | 2.26 (1.62, 3.15) | 13 | 4.2% | 38 | 4.0% | 1.16 (0.62, 2.19)* |
Abbreviation: HR, hazard ratio; CI, confident interval.
a.
Models adjusted for matching factors, race, baseline BMI, baseline Charlson Comorbidity Index.
b.
Women > 50 years old were excluded.
*
Proportional hazards assumption not meant; flexible model used.