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. Author manuscript; available in PMC: 2021 Feb 8.
Published in final edited form as: J Immunol Regen Med. 2020 Oct 21;10:100033. doi: 10.1016/j.regen.2020.100033

Fig. 3. Cardiac matrix educated monocytes recruit MSC.

Fig. 3.

Fig. 3.

A) CXMq (untreated MSC) and CXMq (inhibitor treated MSC) caused significantly greater MSC migration compared to matrix alone without macrophages (CX) and uneducated macrophages (plastic+Mq). Adding fibronectin αVβ3 surface integrin inhibitor to CXMq prevented MSC migration. This suggests that matrix-assembled (insoluble) fibronectin may be linked to monocyte education. (B) Pseudoplot showing decrease in the αVβ3 surface integrin upon treatment with its inhibitor Cyclo-RGDfk (TargetMol, MA). (* p < 0.05), (n=3).