. 2020 Sep 8;30(9):1288–1296. doi: 10.1089/thy.2019.0514

Table 1.

Overview of Missense Mutations in BRAF^V600E Positive Samples at Baseline and at Progression Under BRAF Inhibitors

Patient	Mutations in baseline sample					Mutations in resistant sample
Patient	NCBI accession No.	Name	DNA change	Protein change	Variant allele frequency (%)	NCBI accession No.	Name	DNA change	Protein change	Variant allele frequency (%)
1	NM_004333.4	BRAF	c.1799T>A	p.V600E	—	NM_004333.4	BRAF	c.1799T>A	p.V600E	—
1						NM_004985.3	KRAS	c.35G>T	p.G12V
2	NM_004333.4	BRAF^a	c.1799T>A	p.V600E	26.4	NM_004333.4	BRAF	c.1799T>A	p.V600E	—
	NM_000546.5	TP53^a	c.524G>A	p.R175H	22.3	NM_000546.5	TP53	c.524G>A	p.R175H	—
	NM_ 005228.4	EGFR^a		p.G322S	1.6	—	—	—	—	—
						NM_002524.4	NRAS	c.181C>A	p.Q61K	—
						NM_005157.4	ABL1	c.740A>G	p.K247R	—
3	NM_004333.4	BRAF^a	c.1799T>A	p.V600E	0.4	NM_004333.4	BRAF	c.1799T>A	p.V600E	—
	NM_000051.3	ATM	c.5956A>G	p.I1986V	—	NM_000051.3	ATM	c.5956A>G	p.I1986V	—
	NM_021960.4	MCL1	c.1051dupT	Nonsense	—	—	—	—	—	—
	NM_000546.5	TP53^a		p.R273H	0.4	NM_004985.3	KRAS	c.35G>T	p.G12V	—
	NM_ 005228.4	EGFR^a		p.R776H	0.2	NM_001626.4	AKT2	c.49G>A	p.E17K	—
	NM_001012331.1	NTRK1^a		p.H571Y	0.6	NM_198253.2	TERT (promoter)	c.-124C>T	—	—
	NM_004958.3	MTOR^a		p.V169I	0.3
4	NM_004333.4	BRAF	c.1799T>A	p.V600E	—	NM_004333.4	BRAF^a	c.1799T>A	p.V600E	0.3
4						NM_002524.4	NRAS^a	c.38G>A	p.G13D	0.3

^{^a}

Indicates that the mutations were detected on liquid biopsy (cfDNA, Guardant 360).