Table 3.
Birth outcomes of periconceptionally DTG- and EFV- exposed women, Brazil, 2015-2018.
| Only EFV regimen (N=1068) |
Any DTG regimen (N=384) |
P valuea | |
|---|---|---|---|
| Birth outcomes | |||
| Neural tube defects, n (%) | 0 (0) | 0 (0) | - |
| Outcome | 0·0037 | ||
| Live birth | 1025 (96) | 359 (93) | |
| Stillbirth | 15 (1) | 2 (1) | |
| Abortion | 28 (3) | 23 (6) | |
| Fetus number | 0·014 | ||
| Singleton | 1024 (96) | 380 (99) | |
| Twin | 38 (3) | 4 (1) | |
| Triplet | 6 (1) | 0 (0) | |
| Sex, Gestational Age & Anthropometries | |||
| Male sexb | 526 (51) | 172 (48) | 0·24 |
| Gestational age at delivery in weeksc,median [IQR] | 39 [38-39] | 39 [38-39] | 0·85 |
| Birth weightd (grams) | 3048 [2740-3365] | 3012 [2748-3310] | 0·44 |
| Other congenital birth defectse | |||
| Any congenital abnormality | 59 (6) | 18 (5) | 0·53 |
| Polydactyly | 1 (0) | 1 (0) | 0·45 |
| Talipes equinovarus | 4 (0) | 0 (0) | 0·23 |
| Cleft palate | 0 (0) | 2 (1) | 0·018 |
| Cardiac birth defect | 5 (0) | 1 (0) | 0·59 |
| Digestive system birth defects | 3 (0) | 0 (0) | 0·30 |
| Urinary system birth defects | 0 (0) | 1 (0) | 0·095 |
| Genitalia abnormality | 2 (0) | 1 (0) | 0·79 |
| Other birth defects | 4 (0) | 1 (0) | 0·74 |
a
Continuous variables examined using Wilcoxon rank-sum test and categorical variables examined using Chi square test of proportions.
b
Sex data available for 1384 infants.
c
Gestational age at delivery data available for 1321 infants.
d
Birth weight data available for 1363 infants.
e
Congenital defects as recorded in any birth outcome.
Abbreviations used:
EFV: efavirenz
DTG: dolutegravir
ART: antiretroviral therapy
IQR: interquartile range