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. 2021 Jan 8;7(2):154–164. doi: 10.1002/cjp2.194

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© 2021 The Authors. The Journal of Pathology: Clinical Research published by The Pathological Society of Great Britain and Ireland & John Wiley & Sons, Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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The changes of related proteins after PRMT5 knockdown. Cyclin D1, Bcl‐2, and c‐myc proteins were significantly reduced, while p53 expression was increased after knockdown of PRMT5 in Ishikawa cells. PRMT5^a and GAPDH^b: the bands of PRMT5 and GAPDH (SC and shPRMT5) shown here are the same as those in Figure 3A but for different purposes; we aim to show the relationship between PRMT5 and involved signaling pathways here. SC, scrambled control; shPRMT5, short hairpin PRMT5.