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. Author manuscript; available in PMC: 2022 Feb 5.
Published in final edited form as: Circ Res. 2020 Dec 2;128(3):335–357. doi: 10.1161/CIRCRESAHA.120.316738

Fig. 8.

Fig. 8.

A-C: Heatmap (A) with Euclidean hierarchical clustering of lipid species (lipid species that are listed on the right side of the heat map are described in Online Table XVII). Cardiac lipid species representation to total lipidome (presented as fold-change compared to non-diabetic wt mice) in non-diabetic C57BL/6 mice, diabetic C57BL/6 mice, diabetic Pparα−/− mice, diabetic C57BL/6 mice treated with ML264, diabetic aMHC-Klf5−/− mice and aMHC-rtTA-Klf5 mice fed on doxycycline-enriched diet for 10 days; FC; free cholesterol, CE; cholesterol ester, AC; acylcarnitines, MG; monoglycerides, DG; diacylglycerols, TG; triglycerides, Cer; ceramides, dhCer; dihydroceramides, SM; sphingomyelins, dhSM; dihydrosphingomyelins, MhCer; monohexosylceramides, Sulf; sulfatides, LacCer; lactosylceramides, GM3; gangliosides, GB3; globotrioseacylceramides) (B) and PA; phosphatidic acids, PC; phosphatidylcholines, PCe; phosphatidylcholine ethers, PE; phosphatidylethanolamines, PEp; plasmalogen phosphatidylethanolamines, PS; phosphatidylserines, PI; phosphatidylinositols, PG; phosphatidylglycerols, BMP; bis(monoacylglycero)phosphates, AcylPG; acylphosphatidylglycerols, LPC; lysophosphosphatidylcholines, LPCe; lysophosphosphatidylcholine ethers, LPE; lysophosphatidylethanolamines, LPEp; plasmalogen lysophosphatidylethanolamines, LPI; lysophosphatidylinositols and LPS; lysophosphatidylserines (C). D-E; Heatmaps of ceramides family (D) and diacylglycerol family (E) in non-diabetic C57BL/6 mice, diabetic C57BL/6 mice, diabetic Pparα−/− mice, diabetic C57BL/6 mice treated with ML264, diabetic αMHC-Klf5−/− mice, and αMHC-rtTA-Klf5 mice fed on doxycycline-enriched diet for 10 days. F: Schematic representation of the proposed model about pathways that are involved in diabetic cardiomyopathy.