Table 2. Respiratory, biological and microcirculatory data between severe and critical patients.
| Variables | Severe group (n = 14) | Critical group (n = 29) | P value |
|---|---|---|---|
| HR; bpm | 96 [76–114] | 87 [68–94] | 0.468 |
| MAP; mm Hg | 95 [76–98] | 81 [73–92] | 0.117 |
| SpO2; % | 98 [96–100] | 95 [94–96] | 0.239 |
| Cardiac output; l min-1 | 5.6 [4.0–6.6] | 5.0 [4.0–6.6] | 0.642 |
| LVEF; % | 60 [59–70] | 55 [50–60] | 0.085 |
| Norepinephrine use; n (%) | 0 (0) | 13 (45) | 0.003 |
| Median dose; μg.kg.min-1 | - | 0.02 | NA |
| CRT; sec | 2 [1–3] | 3 [2–4] | 0.06 |
| Mottling score | |||
| 0 | 13 (93) | 17 (59) | |
| 1 | 0 (0) | 7 (24) | |
| 2 | 1 (7) | 3 (10) | 0.110 |
| 3 | 0 (0) | 0 (0) | |
| >3 | 0 (0) | 2 (7) | |
| Blood gases analysis | |||
| pH | 7.46 [7.45–7.48] | 7.36 [7.3–7.38] | <0.0001 |
| PaCO2; mmHg | 36 [33–37] | 49 [44–55] | <0.0001 |
| PaO2; mmHg | 79 [71–110] | 84 [74–100] | 0.746 |
| Lactate; mmol l-1 | 1.5 [1.1–1.7] | 2.0 [1.7–2.5] | 0.001 |
| Ventilation settings | |||
| Compliance; ml H2O -1 | - | 41 [32–44] | - |
| PEEP; cmH2O | - | 14 [12–15] | - |
| Tidal volume; ml kg -1 | - | 5.5 [4.6–6.3] | - |
| PaO2/FiO2 | - | 131 [91–145] | - |
| Plateau pressure; cmH2O | - | 25 [23–26] | - |
| Time from ICU admission to | |||
| inclusion; hours | 20 [5–32] | 21 [6–30] | 0.682 |
| HFNO before inclusion; hours | 20 [5–32] | - | - |
| Microcirculatory parameters | |||
| MFI | 2.5 ± 0.3 | 2.8 ± 0.2 | 0.001 |
| PVD; mm.mm-2 | 10.1 ± 2.4 | 12.5 ± 3.0 | 0.020 |
| PPV; % | 98 ± 3 | 94 ± 9 | 0.090 |
| TVD; mm.mm-2 | 13.8 ± 3.1 | 15.5 ± 3.3 | 0.224 |
| DBS; n vessels.mm-2 | 10.8 ± 2.0 | 12.7 ± 2.6 | 0.033 |
| Heterogeneity index | 0.05 ± 0.06 | 0.1 ± 0.1 | 0.189 |
| Went for mechanical ventilation within the 7 next days; n (%) | 7 (50) | - | - |
| Duration of intubation; days | 20 [15–29] | 22 [16–32] | 0.104 |
| ICU mortality; n (%) | 1 (8) | 7 (24) | <0.0001 |
| Discharge from ICU; n (%) | 13 (93) | 21 (72) | <0.0001 |
| Discharge from hospital; (n%) | 11 (79) | 19 (66) | <0.0001 |
HR: heart rate; MAP: mean arterial pressure; LVEF: left ventricular ejection fraction; CRT: capillary refill time; PEEP: positive end expiratory pressure; ICU: intensive care unit; MFI: microvascular flow index; PVD: perfused vessel density; TVD: total vessel density; PPV: proportion of perfused vessel; DBS: De Backer Score; NA: non-applicable. HFNO: High flow nasal oxygen. Data were expressed as median [interquartile range] or as number (percentage). Data were compared using Mann-Whitney, Chi-2 or a Fischer exact test.