Appendix 1—figure 3. Graphical display of subsampled power-law distributions.
(A-D) Show various ways of displaying clone size distributions obtained by subsampling an underlying clone size distribution consisting of 108 clones drawn according to to various sampling depths. (A) The empirical probability density function of clone sizes, (B) its cumulative density, as well as (C) the cumulative density of normalized clone sizes are not invariant under changes of the sampling depth. Only the tail behavior of relative frequencies of finding cells from large clones is reproducibly captured, which makes rank-frequency plots (displays of unnormalized cumulative distributions of normalized clone sizes) the method of choice for collapsing clone size distributions at various sampling depths.