Table 1.

Top 15 hub genes with a higher degree of connectivity.

NO.	Gene symbol	Full name	Function
1	TLR2	Toll like receptor 2	Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components.
2	FPR2	Formyl peptide receptor 2	Binding of FMLP to the receptor causes activation of neutrophils.
3	MMP9	Matrix metallopeptidase 9	May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration.
4	MPO	Myeloperoxidase	Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms.
5	CEACAM8	Carcinoembryonic antigen related cell adhesion molecule 8	Belongs to the immunoglobulin superfamily; CEA family.
6	ELANE	Elastase, neutrophil expressed	Neutrophil elastase; Modifies the functions of natural killer cells, monocytes and granulocytes.
7	CTLA4	Cytotoxic T-lymphocyte associated protein 4	Inhibitory receptor acting as a major negative regulator of T-cell responses.
8	FCGR1A	Fc fragment of IgG receptor 1A	High affinity receptor for the Fc region of immunoglobulins gamma.
9	SELP	Selectin P	Belongs to the family of cell adhesion molecules. Mediates the interaction of activated endothelial cells or platelets with leukocytes.
10	ARG1	Arginase 1	Key element of the urea cycle, which are vital bioenergy pathways for driving collagen synthesis and cell proliferation.
11	LTF	Lactotransferrin	Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions.
12	HP	Haptoglobin	Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage.
13	LCN2	Lipocalin 2	Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development.
14	GNG10	G protein subunit gamma 10	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems.
15	ADCY3	Adenylate cyclase 3	Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.