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. 2021 Feb 1;2021:4657014. doi: 10.1155/2021/4657014

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Copyright © 2021 Guoqing Tang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

P. acnes caused the pyroptosis of NPCs via ROS-NLRP3 pathway. (a) Flow cytometry analysis suggested that P. acnes caused the overexpression of ROS in NPCs in a time-dependent manner. (b) Neutralization of P. acnes-induced ROS attenuated the pyroptosis of NPCs according to flow cytometry. (c) Neutralization of P. acnes-induced ROS attenuated the overexpression of pyroptosis-related proteins. (d) The pyroptosis of NPCs significantly decreased when NLPR3 was inhibited with MCC950, according to FCM analysis. (e) Inhibition of NLRP3 attenuated the overexpression of pyroptosis-related proteins. One-way ANOVA and Bonferroni tests were used for statistical analysis. ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001 when comparisons were made between groups. All of the values were expressed as mean ± SD.