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. 2021 Feb 1;2021:8899863. doi: 10.1155/2021/8899863

Figure 3.

Figure 3

miR-769-5p mimics alleviated LPS-induced PDLC injury. (a) The expression of miR-769-5p was detected by qRT-PCR in gingival tissues of patients with CP and healthy controls. ∗∗P < 0.01 vs. healthy controls. (b) The expression of miR-769-5p was detected by qRT-PCR in LPS-treated PDLCs and control cells. ∗∗P < 0.01 vs. control cells. (c) The expression of miR-769-5p was detected by qRT-PCR in PDLCs transfected with miR-NC, miR-769-5p mimics, or miR-769-5p inhibitor. ∗∗P < 0.01 vs. the miR-NC group. (d) Cell viability was detected by MTT assay in LPS-treated PDLCs transfected with miR-NC or miR-769-5p mimics. ∗∗P < 0.01 vs. the miR-NC group. (e–g) The concentrations of IL-6, IL-1β, and TNF-α were measured by ELISA in supernatants of LPS-treated PDLCs transfected with miR-NC or miR-769-5p mimics. ∗∗P < 0.01 vs. the miR-NC group. (h) The protein levels of Bax and Bcl-2 were detected by western blot in LPS-treated PDLCs transfected with miR-NC or miR-769-5p mimics. ∗∗P < 0.01 vs. the miR-NC group. (i) The protein level of caspase-3 was detected by western blot in LPS-treated PDLCs transfected with miR-NC or miR-769-5p mimics. ∗∗P < 0.01 vs. the miR-NC group.