Table 4. Comparison of collagen fibers, glucocorticoid receptor-positive nuclei, and mineralocorticoid receptor-immunoreactive areas between the two groups.
| Percentage of collagen fibers |
Percentage of GCR-positive nuclei |
Percentage of MCR-immunoreactive areas |
||||
|---|---|---|---|---|---|---|
| C group (%) | P group (%) | C group (%) | P group (%) | C group (%) | P group (%) | |
| LVFW | 0.83 × 10−1 | 5.43 × 10−1** | 3.17 | 0.31** | 2.57 × 10−3 | 20.03 × 10−3* |
| (0.57–5.34 × 10−1) | (0.34–9.78 × 10−1) | (2.53–4.32) | (0.00–2.10) | (0.34–9.0 × 10−3) | (5.00–73.33 × 10−3) | |
| RVFW | 3.59 × 10−1 | 4.91 × 10−1 | 2.40 | 0** | 0.21 × 10−3 | 49.67 × 10−3** |
| (1.59–29.1 × 10−1) | (0.14–8.17 × 10−1) | (1.21–4.85) | (0.00–2.64) | (0.06–16.67 × 10−3) | (7.00–94.33 × 10−3) | |
| IVS | 1.48 × 10−1 | 3.82 × 10−1* | 3.48 | 0.27** | 1.86 × 10−3 | 20.67 × 10−3 |
| (0.92–2.30 × 10−1) | (0.63–4.72 × 10−1) | (0.99–7.25) | (0.00–0.67) | (0.67–39.33 × 10−3) | (3.33–35.67 × 10−3) | |
| Aorta | 20 | 26.94 | 0.13 × 10−3 | 0 | 0.98 × 10−3 | 1.05 × 10−3 |
| (13.67–32.94) | (11.68–39.65) | (0.00–1.67 × 10−3) | (0.00–1.03 × 10−3) | (0.17–2.69 × 10−3) | (0.07–1.67 × 10−3) | |
C group: control group; GCR: glucocorticoid receptor; IVS: interventricular septal; LVFW: left ventricular free wall; MCR: mineralocorticoid receptor; P group: high-dose prednisolone group; RVFW: right ventricular free wall. For each tissue section, the area of collagen fibers stained with aniline blue was measured in three randomly selected visual fields at 200× magnification. For three randomly selected fields at 400× magnification, the number of GCR-positive and GCR-negative nuclei were counted, and MCR immunostaining-positive sites were measured at fields of view. Data are expressed as medians (range). * and ** Indicate significant difference between the two groups at P<0.05 and P<0.01, respectively.