Table 3. Changes in rectal temperature (RT), heart rate (HR), and non-invasive mean arterial blood pressure (NMABP) in dogs receiving the intramuscular (IM) dose of alfaxalone following the premedication.
| Baseline | 0 min | 5 min | 10 min | 15 min | 20 min | 30 min | 45 min | 60 min | 90 min | 120 min | 180 min | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RT (°C) | |||||||||||||
| MA-1 | 38.3 [38.0–38.8] (6) | 38.7 [38.0–38.9] (6) | 38.5 [37.8–39.0] (6) | 38.4 [37.7–39.1] (6) | 38.3 [37.4–38.8] (6) | 38.1 [37.0–38.7] (6) | 37.7 [36.4–38.5] (6) | 37.2 [35.8–37.9] (6) i | 37.1 [36.2–37.9] (6) i | N. D. | N. D. | N. D. | |
| MA-2.5 | 38.4 [37.7–39.4] (6) | 38.8 [37.5–39.1] (6) | 38.8 [37.2–39.2] (6) | 38.5 [37.2–39.0] (6) | 38.4 [37.1–38.8] (6) | 38.2 [36.7–38.6] (6) | 37.7 [36.3–38.3] (6) | 37.1 [35.8–37.8] (6) | 37.1 [35.3–37.5] (6) i | 36.9 [35.2–37.7] (6) i | 36.3 [35.2–36.7] (3) | N. D. | |
| MA-5 | 38.6 [38.3–39.1] (6) | 38.8 [37.8–39.1] (6) | 38.4 [37.6–39.2] (6) | 38.1 [37.0–38.9] (6) | 38.0 [36.5–38.8] (6) | 37.9 [36.5–38.6] (6) | 37.6 [36.2–38.4] (6) | 37.1 [35.6–38.0] (6) i | 36.7 [35.0–38.2] (6) i | 36.2 [34.9–37.9] (5) i | 36.1 [34.9–37.2] (4) | N. D. | |
| BA-1 | 38.6 [38.2–39.0] (6) | 38.7 [38.1–39.2] (6) | 38.5 [38.0–39.2] (6) | 38.4 [37.9–39.0] (6) | 38.3 [37.8–39.0] (6) | 38.3 [37.7–38.8] (6) | 38.0 [37.4–38.7] (6) | 37.8 [37.0–38.7] (6) | 37.9 [37.5–38.6] (6) | N. D. | N. D. | N. D. | |
| BA-2.5 | 38.7 [38.1–39.1] (6) | 38.9 [38.0–39.2] (6) | 38.8 [37.5–39.0] (6) | 38.5 [37.6–38.8] (6) | 38.3 [37.2–38.7] (6) | 38.3 [37.1–38.7] (6) | 38.2 [37.1–38.7] (6) | 37.9 [36.7–38.1] (6) i | 37.6 [36.6–38.1] (6) i | 37.4 [37.1–38.5] (3) | N. D. | N. D. | |
| BA-5 | 38.7 [38.4–39.0] (6) | 38.7 [38.4–39.2] (6) | 38.7 [38.3–39.1] (6) | 38.6 [38.3–38.9] (6) | 38.4 [38.1–38.7] (6) | 38.4 [38.0–38.5] (6) | 38.1 [37.5–38.2] (6) i | 37.8 [37.4–37.9] (6) i | 37.5 [37.1–37.7] (6) i | 37.2 [36.4–37.4] (6) i | 38.0 [36.5–38.3] (3) | N. D. | |
| MBA-1 | 39.0 [38.7–39.9] (6) | 39.0 [38.1–39.4] (6) | 38.5 [37.5–39.0] (6) | 38.3 [37.3–38.8] (6) | 38.2 [37.2–38.7] (6) | 38.1 [37.0–38.5] (6) i | 37.5 [36.7–38.2] (6) i | 37.3 [36.2–37.8] (6) i | 36.8 [35.8–37.6] (6) i | 36.5 [35.0–37.0] (6) i | 35.9 [35.7–37.0] (4) | N. D. | |
| MBA-2.5 | 38.8 [38.0–39.0] (6) | 38.6 [38.3–39.0] (6) | 38.4 [38.0–38.8] (6) | 38.5 [37.6–38.7] (6) | 38.3 [37.4–38.4] (6) | 37.9 [37.0–38.4] (6) | 37.8 [37.0–38.2] (6) | 37.5 [36.5–38.0] (6) i | 37.2 [36.2–37.9] (6) i | 36.6 [35.5–37.6] (6) i | 36.3 [35.5–37.3] (6) i | 37.1 [36.6–37.7] (4) | |
| MBA-5 | 38.6 [38.3–39.1] (6) | 38.7 [38.2–39.1] (6) | 38.4 [38.1–38.8] (6) | 38.3 [37.7–38.8] (6) | 38.2 [37.6–38.6] (6) | 38.1 [37.4–38.7] (6) | 37.9 [37.0–38.3] (6) i | 37.5 [36.3–38.0] (6) i | 37.1 [35.9–38.0] (6) i | 36.4 [35.2–37.4] (6) i | 36.4 [35.0–37.0] (6) i | 36.5 [35.2–37.7] (5) | |
| HR (beats/min) | |||||||||||||
| MA-1 | 96 [64–112] (6) | 50 [36–64] (6) | 44 [24–60] (6) i | 43 [28–52] (6) i | 41 [30–56] (6) i | 41 [32–50] (6) i | 43 [24–52] (6) i | 41 [34–72] (6) | 53 [28–78] (6) | N. D. | N. D. | N. D. | |
| MA-2.5 | 96 [80–108] (6) | 60 [44–72] (6) i | 44 [40–60] (6) i | 48 [44–64] (6) i | 56 [40–60] (6) i | 56 [38–64] (6) i | 52 [34–64] (6) i | 52 [38–64] (6) i | 44 [34–66] (6) i | 56 [38–84] (6) | 36 [34–58] (3) | N. D. | |
| MA-5 | 72 [64–108] (6) | 47 [34–56] (6) | 54 [47–68] (6) a, i | 59 [50–78] (6) a | 59 [50–78] (6) aa | 64 [50–80] (6) aa | 56 [42–82] (6) | 58 [44–64] (6) | 55 [38–64] (6) i | 70 [40–92] (6) | 64 [36–72] (5) | N. D. | |
| BA-1 | 102 [72–124] (6) | 82 [68–100] (6) a | 88 [68–124] (6) a | 78 [68–116] (6) aa | 76 [64–120] (6) a | 82 [68–112] (6) aa | 70 [64–104] (6) aa | 66 [60–104] (6) | 86 [64–96] (6) | N. D. | N. D. | N. D. | |
| BA-2.5 | 92 [72–124] (6) | 79 [68–104] (6) | 80 [52–120] (6) | 84 [72–124] (6) | 88 [64–124] (6) b | 84 [72–116] (6) | 81 [68–116] (6) b | 76 [44–88] (6) b | 86 [64–132] (6) b | 88 [88–124] (3) | N. D. | N. D. | |
| BA-5 | 96 [88–124] (6) | 88 [68–116] (6) | 102 [68–128] (6) c, e | 88 [76–148] (6) c | 98 [76–136] (6) cc | 88 [80–124] (6) cc | 86 [72–108] (6) c | 76 [72–92] (6) c | 70 [60–83] (6) e, i | 99 [68–184] (6) | 86 [72–108] (3) | N. D. | |
| MBA-1 | 128 [80–144] (6) | 46 [40–72] (6) d, i | 42 [32–60] (6) d, i | 50 [32–76] (6) i | 48 [32–72] (6) d, i | 48 [32–72] (6) i | 50 [28–72] (6) i | 52 [28–68] (6) i | 51 [28–80] (6) i | 50 [44–76] (6) i | 46 [36–56] (4) | N. D. | |
| MBA-2.5 | 116 [88–164] (6) | 48 [32–60] (6) ee, i | 44 [32–60] (6) ee, i | 42 [36–64] (6) ee, i | 48 [40–64] (6) e, i | 50 [40–60] (6) i | 48 [36–60] (6) e,i | 48 [40–60] (6) e, i | 48 [36–60] (6) e, i | 42 [40–56] (6) i | 46 [32–76] (6) i | 75 [68–80] (4) | |
| MBA-5 | 116 [88–160] (6) | 43 [36–52] (6) f, i | 52 [36–68] (6) f, i | 70 [56–92] (6) h | 74 [48–100] (6) g, h | 72 [48–96] (6) g | 62 [44–86] (6) i | 54 [40–72] (6) f, i | 54 [36–76] (6) f, i | 52 [32–64] (6) i | 50 [36–92] (6) | 80 [50–120] (5) | |
| NMABP (mmHg) | |||||||||||||
| MA-1 | 142 [105–183] (6) | 102 [100–116] (6) | 120 [92–154] (6) | 106 [96–111] (6) | 114 [102–151] (5) | 108 [103–134] (5) | 107 [90–112] (5) | 105 [90–117] (6) | 104 [95–161] (5) | N. D. | N. D. | N. D. | |
| MA-2.5 | 119 [89–158] (6) | 116 [103–166] (6) | 122 [101–144] (6) | 127 [96–133] (6) | 123 [100–125] (6) | 114 [101–119] (6) | 110 [101–120] (6) | 101 [93–118] (6) | 103 [94–137] (6) | 119 [84–139] (6) | 123 [119–123] (3) | N. D. | |
| MA-5 | 129 [100–152] (6) | 113 [95–150] (6) | 136 [101–176] (6) a | 124 [105–150] (6) a | 121 [105–145] (6) | 113 [97–141] (6) | 108 [97–135] (6) | 98 [77–130] (6) | 94 [76–144] (6) | 107 [96–163] (6) | 112 [95–116] (5) | N. D. | |
| BA-1 | 120 [89–141] (6) | 92 [82–99] (6) | 88 [74–107] (6) | 89 [77–107] (6) | 88 [76–96] (6) aa | 89 [80–101] (6) aa | 88 [79–99] (6) a | 94 [84–102] (6) | 97 [77–109] (6) | N. D. | N. D. | N. D. | |
| BA-2.5 | 112 [92–151] (6) | 96 [86–115] (6) | 89 [74–117] (6) b | 87 [82–106] (6) b | 87 [79–96] (6) b | 87 [81–95] (6) bb | 81 [75–101] (6) b | 82 [71–96] (6) b | 91 [78–99] (6) | 100 [88–128] (3) | N. D. | N. D. | |
| BA-5 | 121 [101–140] (6) | 99 [80–111] (6) c | 90 [82–109] (6) c | 88 [80–110] (6) c | 84 [76–98] (6) c, i | 82 [75–102] (6) c | 87 [74–101] (6) c,i | 86 [65–91] (6) d, i | 83 [81–94] (6) i | 92 [82–132] (6) | 97 [89–107] (3) | N. D. | |
| MBA-1 | 121 [104–144] (6) | 105 [97–158] (6) dd | 115 [105–120] (6) | 111 [101–120] (6) dd | 104 [96–110] (6) | 98 [89–122] (6) | 94 [78–106] (6) | 85 [73–91] (6) a, i | 84 [74–92] (6) aa, i | 93 [69–109] (6) | 86 [69–104] (4) | N. D. | |
| MBA-2.5 | 106 [92–124] (6) | 115 [54–121] (6) | 120 [94–126] (6) | 117 [76–130] (6) | 109 [91–149] (6) e | 107 [98–109] (6) | 95 [83–113] (6) | 88 [82–104] (6) | 88 [79–104] (6) | 85 [70–108] (6) | 94 [78–121] (6) | 104 [96–122] (4) | |
| MBA-5 | 118 [101–123] (6) | 118 [102–125] (6) f | 125 [106–167] (6) | 126 [118–163] (6) f | 117 [109–139] (6) f | 112 [99–137] (6) | 101 [89–110] (6) | 89 [83–95] (6) i | 88 [79–99] (6) i | 80 [75–141] (6) | 85 [76–117] (6) | 104 [81–114] (5) | |
Data was reported as median [minimum-maximum] and the number of dogs used to calculate the median was shown in parentheses. N. D.: not done. See the explanation in regarding nine anesthesia treatments in Table 1. Significant difference from MA-1: a) P<0.05, aa) P<0.01. Significant difference from MA-2.5: b) P<0.05, bb) P<0.01. Significant difference from MA-5: c) P<0.05, cc) P<0.01. Significant difference from BA-1: d) P<0.05, dd) P<0.01. Significant difference from BA-2.5: e) P<0.05. Significant difference from BA-5: f) P<0.05. Significant difference from MBA-1: g) P<0.05. Significant difference from MBA-2.5: h) P<0.05. Significant difference from the baseline value: i) P<0.05.