Table 2.
Overview of MRI changes reported in LBSL.
| MRI Changes | LBSL (n = 83)a, proportion of patients (%) |
|---|---|
| Supratentorial | |
| Cerebral WM with subcortical sparing* | 92.8 |
| Posterior part of the corpus callosum | 77.1 |
| Posterior limb of the internal capsule | 81.9 |
| Infratentorial | |
| Lateral corticospinal tracts or dorsal columns of the spinal cord | 89.2 |
| Pyramidal tract and/or medial lemniscus of the brainstem | 94.0 |
| Superior cerebellar peduncles | 73.5 |
| Inferior cerebellar peduncles | 69.9 |
| Intraparenchymal trajectories of the trigeminal nerve | 63.9 |
| Mesencephalic trigeminal tracts | 47.0 |
| Anterior spinocerebellar tracts of the medulla oblongata | 32.5 |
| Cerebellar white matter | 88.0 |
Adapted, with some modifications, from the MRI criteria described by Steenweg et al. (2012). Only data from full-text publications was included in this table. MRI changes were deemed to be not present if the feature was not mentioned, not investigated, or if they were stated to be normal.
Patients with cerebral white matter changes, but without subcortical u-fiber sparing, were not included in this count.
References: (Van Der Knaap et al., 2003; Linnankivi et al., 2004; Serkov et al., 2004; Petzold et al., 2006; Labauge et al., 2007, 2011; Távora et al., 2007; Uluc et al., 2008; Erturk et al., 2010; Isohanni et al., 2010; Lin et al., 2010; Galluzzi et al., 2011; Mierzewska et al., 2011; Miyake et al., 2011; Orcesi et al., 2011; Sharma et al., 2011; Synofzik et al., 2011; Moore et al., 2012; Steenweg et al., 2012; Tzoulis et al., 2012; Cheng et al., 2013; Martikainen et al., 2013; Schicks et al., 2013; Alibas et al., 2014; Kassem et al., 2014; Tylki-Szymanska et al., 2014; Kohler et al., 2015; Navarro Vázquez et al., 2016; Lan et al., 2017; Shimojima et al., 2017; Cavusoglu et al., 2018; Gonzalez-Serrano et al., 2018; Werner et al., 2018; Yahia et al., 2018; Yelam et al., 2019; Ikazabo et al., 2020).