Table 3.
Mixed-model regression of geographic atrophy area according to the presence or absence of subsequent exudative neovascular age-related macular degeneration, in the incident geographic atrophy cohort, according to different follow-up periods.
| Number of eyes (participants) | Change per year in square root of GA area | Change per year in GA area | |||||
|---|---|---|---|---|---|---|---|
| Estimate (mm) | 95% CI (mm) | P* | Estimate (mm) | 95% CI (mm) | P* | ||
| Full duration of follow-up included | |||||||
| Incident GA without subsequent exudative NV-AMD† | 684 (561) | 0.29 | 0.27–0.30 | 0.037 | 1.13 | 1.05–1.20 | 0.004 |
| Incident GA with subsequent exudative NV-AMD† | 73 (73) | 0.20 | 0.12–0.28 | 0.62 | 0.29–0.96 | ||
| Follow-up limited to 3 years only | |||||||
| Incident GA without subsequent exudative NV-AMD | 684 (561) | 0.29 | 0.27–0.31 | 0.041 | 1.12 | 1.03–1.20 | 0.007 |
| Incident GA with subsequent exudative NV-AMD | 73 (73) | 0.21 | 0.13–0.29 | 0.65 | 0.32–0.98 | ||
| Follow-up limited to 2 years only | |||||||
| Incident GA without subsequent exudative NV-AMD | 684 (561) | 0.30 | 0.27–0.32 | 0.031 | 1.08 | 0.98–1.18 | 0.010 |
| Incident GA with subsequent exudative NV-AMD | 73 (73) | 0.20 | 0.11–0.28 | 0.60 | 0.25–0.95 | ||
Abbreviations: CI = confidence interval; GA = geographic atrophy; NV-AMD = neovascular age-related macular degeneration.
P values for interaction between presence/absence of subsequent exudative neovascular age-related macular degeneration and years from first appearance of geographic atrophy.
Same results as in Table 2 (shown for comparison).