Table 1.
Baseline characteristics by HDL quartiles
| Characteristics | HDL quartiles | P-value* | |||
|---|---|---|---|---|---|
| Q1 (<38mg/dL) | Q2 (38–46.9mg/dL) | Q3 (47–58.9mg/dL) | Q4 (≥59mg/dL) | ||
| Age, Median (IQR) | 57(52–62) | 57(52–62) | 56(52–62) | 56(52–61) | <0.01 |
| Race | |||||
| White | 2833(84.2) | 2847(77.8) | 2155(71.5) | 2431(70.7) | <0.01 |
| Gender | |||||
| Female | 912(27.1) | 1720(47.0) | 2042(67.8) | 2819(81.9) | <0.01 |
| Center | |||||
| Forsyth County NC | 956(28.4) | 939(25.7) | 699(23.2) | 864(25.1) | <0.01 |
| Jackson, MS | 463(13.8) | 708(19.4) | 758(25.2) | 894(26.0) | |
| Minneapolis, MN | 861(25.6) | 990(27.1) | 796(26.4) | 997(29.0) | |
| Washington County, MD | 1084(32.2) | 1022(27.9) | 761(25.3) | 686(19.9) | |
| Smoking status | |||||
| Current cigarette smoker | 916(27.2) | 832(22.8) | 599(19.9) | 621(18.1) | <0.01 |
| Former cigarette smoker | 1437(42.8) | 1444(39.5) | 1090(36.2) | 1144(33.3) | |
| Never smoked cigarettes | 1003(29.9) | 1376(37.7) | 1323(43.9) | 1673(48.7) | |
| BMI (kg/m2), Median (IQR) | 28.4(25.8–31.5) | 27.5(24.8–31.0) | 27.0(24.0–30.8) | 25.2(22.5–28.6) | <0.01 |
| Education | |||||
| 12 years or more | 2578(76.8) | 2884(78.9) | 2341(77.8) | 2794(81.3) | <0.01 |
| Medications | |||||
| Cholesterol lowering medication including Statins | 271(8.1) | 261(7.2) | 178(5.9) | 152(4.4) | <0.01 |
| Steroids | 19(0.6) | 46(1.3) | 38(1.3) | 79(2.3) | <0.01 |
| Antineoplastic agents | 17(0.5) | 22(0.6) | 14(0.5) | 25(0.7) | 0.51 |
| Comorbidities | |||||
| Hypertension | 1334(39.8) | 1325(36.3) | 1042(34.7) | 1045(30.5) | <0.01 |
| Diabetes | 681(20.3) | 564(15.5) | 358(11.9) | 216(6.3) | <0.01 |
| COPD | 3(0.1) | 4(0.1) | 0(0) | 3(0.1) | 0.4 |
| Patients with comorbiditiesτ | 1633(48.7) | 1564(42.9) | 1182(39.3) | 1139(33.3) | <0.01 |
| eGFR (mL/min/1.73m2), Median (IQR) | 95.5(85.5–102.9) | 96.6(88.0–104.6) | 98.5(89.8–107.4) | 99.6(91.4–107.8) | <0.01 |
| Hs-CRP (mg/dL) )ξ, Median (IQR) | 2.52(1.28–5.06) | 2.27(1.13–4.91) | 2.22(1.04–4.88) | 1.80(0.83–4.18) | <0.01 |
*
Chi-square tests were used for categorical variables and Wilcoxon rank-sum tests were applied for continuous variables.
ξ
hsCRP collected in total N=12,601 (pneumonia event yes N=1805, no N=10796)
τ
Patients with comorbidities include patients with at least 1 comorbid condition