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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Matrix Biol. 2020 Oct 13;95:1–14. doi: 10.1016/j.matbio.2020.10.001

Fig. 2.

Fig. 2.

Decorin deficiency favors a pro-metastatic environment in the intestinal epithelium of mice treated with AOM/DSS. (A) Ptgs2 and Pge2 expression in neoplastic colonic epithelium at 12 and 21 weeks post AOM/DSS induction. (B) Representative Western blots showing the expression of metastatic markers in the intestinal epithelial tissue of Dcn−/− mice 12- and 21-weeks post AOM/DSS induction. (C) Quantification of E-cadherin, vimentin, Snail, and Twist 1 in the colonic epithelium of Dcn−/− mice treated with AOM/DSS. (D-E) Representative immune-histochemical analysis depicting ICAM-1 expression in the intestinal epithelium of Dcn−/− and Dcn+/+ mice, 12- and 21-weeks post AOM/DSS induction. Bar, 100 μm. Experiments were performed in triplicate. Data are expressed as mean ±S.D. *p<0.05, **p<0.01, **p<0.001.