Table 3.

Linear regression models for the association of age at complication diagnosis with age at natural menopause

Age at complication diagnosis	Age at natural menopause		Unadjusted		Adjusted*
	Mean (SD)	Overall P value	β coefficient (SE)	P value	β coefficient (SE)	P value
Microalbuminuria
<30 yrs (n=25)	47.5±4.9	0.02	−2.40 (1.01)	0.02	−2.06 (1.08)	0.06
≥30 yrs (n=34)	50.2±3.1		0.31 (0.92)	0.74	0.60 (0.99)	0.55
No (n=40)	49.9±4.0		Ref		Ref
Overt nephropathy
<30 yrs (n=12)	47.7±5.8	0.27	−1.78 (1.28)	0.17	−1.42 (1.38)	0.31
≥30 yrs (n=14)	50.3±3.8		0.77 (1.20)	0.52	1.20 (1.28)	0.35
No (n=71)	49.5±3.8		Ref		Ref
Proliferative retinopathy
<30 yrs (n=17)	49.3±4.8	0.95	−0.03 (1.18)	0.98	0.24 (1.22)	0.85
≥30 yrs (n=44)	49.6±3.7		0.26 (0.88)	0.77	0.63 (0.94)	0.50
No (n=42)	49.4±4.1		Ref		Ref
Confirmed distal symmetrical polyneuropathy
<30 yrs (n=10)	48.0±3.4	0.02	−0.44 (1.39)	0.75	0.26 (1.50)	0.87
≥30 yrs (n=40)	50.6±3.0		2.19 (0.86)	0.01	2.95 (0.91)	0.002
No (n=47)	48.4±4.7		Ref		Ref
Coronary artery disease
<30 yrs (n=2)	46.0±4.2	0.37	−3.41 (2.90)	0.24	−3.46 (3.00)	0.25
≥30 yrs (n=23)	50.1±2.7		0.68 (0.96)	0.48	0.93 (0.99)	0.35
No (n=80)	49.4±4.4		Ref		Ref

^*Model allowed for baseline BMI, smoking status, HDL, and HbAlc