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. Author manuscript; available in PMC: 2022 Feb 19.
Published in final edited form as: J Mol Biol. 2020 Dec 31;433(4):166788. doi: 10.1016/j.jmb.2020.166788

Fig 4. Example of distant homology that can be detected by active site similarity.

Fig 4.

RLM SSEs are colored in rainbow with active site residues shown in magenta. (A) DNA-adenine methyltransferase (PDB: 1yf3) binds SAH. (B) 12-hydroxydehydrogenase /15-Oxo-prostaglandin 13-reductase (PDB: 1v3v) binds NADP. (C) Caffeoyl-CoA O-methyltransferase (PDB: 1sus) binds SAH. Sequence homology probability was calculated using HHpred [49], structure similarity score was calculated using DALI [59]. (D) HHpred sequence alignment of caffeoyl-CoA O-methyltransferase (PDB: 1sus) and 12-hydroxydehydrogenase / 15-Oxo-prostaglandin 13-reductase (PDB: 1v3v). Gly residues from Gly-rich loop are colored by magenta. (E) HHpred sequence alignment of caffeoyl-CoA O-methyltransferase (PDB: 1sus) and DNA-adenine methyltransferase (PDB: 1yf3). Gly residues from Gly-rich loop are colored by magenta.