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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Biomaterials. 2021 Jan 8;269:120666. doi: 10.1016/j.biomaterials.2021.120666

Table 1.

Summary of in vivo gene expression changes with treatment compared to PBS. A total of 14,472 genes and 5,944 pathways were analyzed. Note that pro-tumor indicates upregulation of pro-tumor pathways or downregulation of anti-tumor pathways. Similarly, the column anti-tumor indicates upregulation of anti-tumor pathways or downregulation of pro-tumor pathways. The listing of pathways is available in Fig S6.

Upreg. Genes Downreg. Genes Upreg. Pathways Downreg. Pathways Pro-Tumor Anti-Tumor
NP Spleen 243 119 327 264 124 105
Tumor 2 2 353 71 82 75
Lung 15 20 221 623 96 128
NP+αPD-1 Spleen 28 62 612 165 107 97
Tumor 21 13 411 110 125 102
Lung 340 240 84 934 87 148