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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Exp Neurol. 2021 Jan 7;337:113597. doi: 10.1016/j.expneurol.2021.113597

Fig. 3.

Fig. 3.

DNP exerts toxic effects on neuron survival in 4-MO mice at 7 days after spinal cord injury. Tissue obtained from mice at 7-DPI was analyzed for effects of DNP on neuron survival. Images of representative samples taken at 500 μm away from the lesion epicenter (A) demonstrate a significant loss of neurons with all DNP doses in 4- but not 14-MO mice (p < 0.05 for 1.0- and p < 0.005 for 2.5- and 5.0-mg/kg; B). When compared to vehicle-treated mice, no differences were found in a treatment effect with DNP between 4- and 14-MO mice (p = 0.08; C). Scale bars represent 500 μm. Boxes represent analysis regions over the ventral horns, and enlarged images. Arrows point to the central canal. Analyzed using one-way ANOVA for each age (B) or two-way ANOVA (C). Graphs represent mean ± SEM, n = 3-5/group. *p < 0.05, ***p < 0.005 vs. vehicle control.