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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Exp Neurol. 2021 Jan 7;337:113597. doi: 10.1016/j.expneurol.2021.113597

Fig. 4.

Fig. 4.

DNP exerts age-divergent effects on tissue sparing at 7 days after spinal cord injury. The extent of tissue sparing was assessed at 7-DPI after treatment with DNP. Images of representative samples of lesion epicenters (A) demonstrate that treatment with 1.0-mg/kg/day DNP spared tissue in 14- but not 4-MO mice treated (p < 0.05; B). When compared to same age vehicle-treated groups, the 1.0- and 2.5-mg/kg/day DNP doses resulted in significant age divergent responses by reducing tissue sparing in 4-MO SCI mice and preserving tissue in 14-MO SCI mice (C). Scale bars represent 500 μm. Analyzed using one-way ANOVA for each age (B) or two-way ANOVA (C). Graphs represent mean ± SEM, n = 3–5/group. *p < 0.05, **p < 0.01, ***p < 0.001.