Table 4.
Current clinical trials on ex vivo liver machine perfusion
| Title | Status | Features | Identifier |
|---|---|---|---|
| Hypothermic machine perfusion | |||
| Study to evaluate performance of LifePort® Liver Transporter System, a machine perfusion system, for liver transplant | Recruiting | Regular organs, randomized, multicenter | NCT 03484455 |
| Hypothermic oxygenated perfusion for extended criteria donors in liver transplantation (HOPExt) | Recruiting | ECD organs, DBD, randomized, multicenter | NCT 03929523 |
| Post-static cold storage hypothermic oxygenated perfusion in Bergamo Liver Transplant Program | Recruiting | ECD organs, DBD and DCD, observational, single-center | NCT 03098043 |
| Clinical trial of new hypothermic oxygenated perfusion system versus static cold storage | Recruiting | ECD organs, DBD, new HOPE device vs. static cold storage, randomized, single-center | NCT 03837197 |
| Normothermic machine perfusion | |||
| Normothermic liver preservation | Active, not yet recruiting | Regular organs, DBD and DCD, randomized, multicenter | NCT 02775162 |
| Safety and feasibility of normothermic machine perfusion to preserve and evaluate orphan livers | Not yet recruiting | Declined organs, DBD and DCD. single group, single-center | NCT 03456284 |
| Pilot study to assess safety and feasibility of normothermic machine preservation in human liver transplantation | Active, not recruiting | ECD (> 70 years), DBD and DCD, non-randomized | NCT 02515708 |
| Normothermic liver preservation trial | Recruiting | ECD, DBD and DCD, single-center, non-randomized | NCT 03089840 |
| Using ex vivo normothermic machine perfusion with the OrganOx Metra™ device to store human livers for transplantation | Enrolling by invitation | ECD, DBD and DCD mix, non-randomized | NCT 02478151 |
| Viability testing and transplantation of marginal livers | Active, not recruiting | Declined organs, DBD and DCD, single-center, non-randomized | NCT 02740608 |
| Efficacy of ex situ normothermic perfusion versus Cold storage in the transplant with steatotic liver graft | Recruiting | DBD and living donors, 30% - 60% of macrovesicular steatosis, single-center, randomized | NCT 03930459 |
| Sequential perfusion | |||
| Sequential hypo- and normothermic perfusion to preserve extended criteria donor livers for transplantation | Not yet recruiting | ECD, DBD and DCD, single group, single-center | NCT 04023773 |