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. 2021 Feb 8;12(2):160. doi: 10.1038/s41419-021-03452-x

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Kidney Slc7a11 and Gpx4 mRNA expression was significantly lower in STZ mice than the Con group, and changes in the STZ kidney were abrogated by Fer-1 treatment. B xCT and GPX4 protein expression assessed by western blot was significantly lower in the STZ kidney, and this was ameliorated by administration of Fer-1. C TUNEL staining showed a significant increase in cell death in the STZ kidney, which was alleviated by Fer-1 treatment. D Protein and mRNA expression of xCT and GPX4 in kidney samples of db/db mice. E Total iron levels measured in kidney samples of STZ and db/db mice. F Protein and mRNA expression level of FTH1 in kidney samples of STZ and db/db mice. One-way ANOVA and Bonferroni post hoc tests were used for statistical analysis. Error bars represent SD. Original magnification, ×20 for all. Scale bar = 100 µm. **P < 0.01; ***P < 0.001 versus Con group. ^#P < 0.05; ^##P < 0.01; ^###P < 0.001 versus STZ group. n = 10 for each group of STZ. n = 3 for each group of db/db.