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. Author manuscript; available in PMC: 2021 Mar 13.
Published in final edited form as: Mucosal Immunol. 2020 Aug 9;14(2):420–430. doi: 10.1038/s41385-020-0333-3

Figure 6.

Figure 6.

IgG1-ASCs and IgG2-ASCs are the major isotypes of plasma cells substituting for IgA-ASCs in IgA-deficient human patients. (A) Representative microscopic images of colonic sections of IgA-sufficient and IgA-deficient patients immunohistochemically stained for IgA+, IgM+ and IgG+ plasma cells. The sections were H&E counter-stained. (B) Numbers of IgA+, IgM+ and IgG+ plasma cells per representative high-power imaging field (HPF) of colonic sections of IgA-sufficient and IgA-deficient patients. One dot represents one patient sample. (C) Representative microscopic images of colonic sections of IgA-deficient patients immunohistochemically stained for IgG1+, IgG2+, IgG3+ and IgG4+ plasma cells. The sections were H&E counter-stained. (D) Numbers of IgG1+, IgG2+, IgG3+ and IgG4+ plasma cells per representative high-power imaging field of colonic sections of IgA-deficient patients. One dot represents one patient sample. (E) Representative microscopic images of colonic sections of IgA-sufficient and IgA-deficient patients immunohistochemically stained for CCR10+ plasma cells. The sections were H&E counter-stained.