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. 2020 Nov 4;87(2):185–196. doi: 10.1007/s00280-020-04184-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Distribution of simulated exposure metrics following berzosertib recommended dose for different combination regimens. C_max maximum concentration, C_avg average concentration. Distributions of simulated C_max (left) and C_avg (right) following berzosertib single dose of 90 mg/m² (recommended dose for the combination with carboplatin), 140 mg/m² (recommended dose for the combination with cisplatin), and 210 mg/m² (recommended dose for the combination with gemcitabine). Boxes represent interquartile range; horizontal lines are first quartiles, medians, third quartiles; lower whiskers extend from each quartile to the extreme non-outlier values in the dataset; points are outliers. The blue horizontal dashed line represents the p-Chk1 IC50