Table 2.

Demographics and baseline characteristics of combined participants in Studies 001 and 002

Variable	Value (N = 240)
Demographics
Age [years]	60 {58.4} (26–79) [0]
Body weight [kg]	72.8 {75.4} (46–150) [0]
BSA [kg/m2]	1.82 {1.84} (1.4–2.59) [0]
Lean body mass [kg]	49.9 {52.3} (35.7–78.9) [1]
Height [cm]	168 {167} (99–191) [0]
Sex [n (%)]
Male	95 (39.6%)
Female	145 (60.4%)
Race [n (%)]
White	224 (93.3%)
Black	3 (1.25%)
Asian	5 (2.08%)
Other	6 (2.5%)
Missing	2 (0.833%)
Ethnicity [n (%)]
Hispanic/latino	7 (2.92%)
Not hispanic/latino	226 (94.2%)
Missing	7 (2.92%)
Lab values
Creatinine [µmol/L]	66.6 {69.8} (32.7–148) [0]
Creatinine clearance [mL/min]	95 {100} (50–150) [0]
Platelet count [109/L]	274 {289} (93–816) [0]
White cell count [cells/µL]	7.2 {7.65} (1.37–25.2) [0]
Albumin [g/L]	38 {37.6} (23–49) [0]
Bilirubin [µmol/L]	7 {8.16} (0.5–21) [0]
ALT [U/L]	20 {26.9} (4–178) [0]
AST [U/L]	24 {31.1} (9–159) [0]
Renal impairment [n (%)]
None	137 (57.1%)
Mild	88 (36.7%)
Moderate	15 (6.25%)
Severe	0 (0%)
Hepatic impairment [n (%)]
None	166 (69.2%)
Mild	43 (17.9%)
Moderate	0 (0%)
Severe	1 (0.417%)
Missing	30 (12.5%)
Disease status
Tumor burden [mm]	75 {84.1} (10–312) [0]
Tumor type [n (%)]
NSCLC	48 (20.0%)
TNBC	33 (13.8%)
SCLC	16 (6.67%)
PrCa	7 (2.92%)
Breast	11 (4.58%)
H&N	1 (0.417%)
CRC	44 (18.3%)
Ovarian	9 (3.75%)
Mesothelioma	12 (5.0%)
Other	59 (24.6%)
ECOG PS [n (%)]
0	65 (27.1%)
1	164 (68.3%)
2	5 (2.08%)
3	6 (2.5%)

Continuous covariates are reported as median {geometric mean} (range) [missing]. Categorical covariates are reported as number (percentage)

ALT alanine transaminase, AST aspartate transaminase, BSA body surface area, CRC colorectal cancer, ECOG PS Eastern Cooperative Oncology Group Performance Status, H&N head & neck, NSCLC non-small cell lung cancer, PrCa prostate cancer, SCLC small cell lung cancer, TNBC triple-negative breast cancer