Table 1.

LC₅₀ values for senolytic drugs. LC₅₀ values including the 99% confidence intervals for senolytic drugs after treatment for 5 days and 24 h

Drug	Treatment	Control	10 µM SM	40 µM SM	200 µM H2O2
17-DMAG [nM]	5 days	118 ± 13	460 ± 66	510 ± 68	1911 ± 148
17-DMAG [nM]	24 h	31,041 ± 2573	59,457 ± 6661	44,276 ± 5,408	42,871 ± 3036
ABT-263 [µM]	5 days	31.6 ± 0.5	36.1 ± 2.2	33.8 ± 1.5	33.1 ± 0.3
ABT-263 [µM]	24 h	58.1 ± 1.6	48.9 ± 0.9	43.4 ± 1.2	41.7 ± 0.9
ABT-737 [µM]	5 days	115 ± 11	(1054 ± 315)	(2,364 ± 1,403)	(8536 ± 12,628)
Antimycin A [µM]	5 days	560.9 ± 92.3	513.3 ± 39.8	613.3 ± 61.5	586.4 ± 99.6
Dasatinib [nM]	5 days	152 ± 25	2259 ± 362	3692 ± 742	1543 ± 604
Dasatinib [nM]	24 h	1690 ± 813	20,773 ± 7103	11,633 ± 4131	24,457 ± 8867
Etomoxir [µM]	5 days	544 ± 21	568 ± 17	584 ± 17	555 ± 23
FOXO4-DRI [µM]	5 days	44.4 ± 1.8	53.1 ± 2.3	57.7 ± 2.1	56.4 ± 2.3
Quercetin [µM]	5 days	116.0 ± 8.7	104.1 ± 5.4	121.1 ± 7.6	177.2 ± 10.6

Italic values in brakes reflect calculations but are above solubility limit