Fig. 1.

Latent class cluster analysis identified 2 distinct headache clusters in COVID-19. pulmonary infiltration and circulating proinflammatory IL-6 levels had an impact on the formation of both clusters. Severe headache phenotypes classified in Cluster-1 were blocks. Moderate headache phenotypes were classified in Cluster-2, and 94% were responsive to paracetamol. Moderate increase of IL-6 and intact pulmonary imaging in 40% is notable in Cluster-2. Headache in COVID-19 had throbbing quality and was frequently located in the frontal region