Table 1.

Clinical features and main laboratory findings of patients with COVID-19

	Patients with headache n = 83 (28.9%)	Patients without headache n = 204 (71.1%)	p
Age (mean ± SD) Median[min-max]	48.40 ± 15.90 48.00 [20.00–89.00]	46.05 ± 14.87 46.00 [19.00–85.00]	0.236
Gender (women/men) n (%)	35 (42.2%)/48 (57.8%)	92 (45.1%)/12 (54.9%)	0.651
Pulmonary involvement n (%)	63 (75.9%)	69 (33.8%)	< 0.001
Previous primary HA n (%)	12 (14.5%)	21 (10.3%)	0.425
Comorbidities
Hypertension n (%)   DM n (%)   CAD n (%)   Stroke n (%)   Asthma n (%)   COPD n (%)   Obesity n (%)	33 (39.8%)	47 (23.0%)	0.007
	14 (16.9%)	16 (7.8%)	0.040
	8 (9.6%)	9 (4.4%)	0.154
	9 (10.8%)	3 (1.5%)	0.001
	8 (9.6%)	10 (4.9%)	0.218
	9 (10.8%)	9 (4.4%)	0.077
	28 (33.7%)	49 (24.0%)	0.124
Hyposmia n (%)	7 (8.4%)	8 (3.9%)	0.206
Loss of taste n (%)	6 (7.2%)	9 (4.4%)	0.497
Loss of appetite n (%)	45 (54.2%)	28 (13.7%)	< 0.001
Loss of weight n (%)	37 (44.6%)	26 (12.7%)	< 0.001
Diarrhea n (%)	21 (25.3%)	31 (15.2%)	0.044
IL-6 (mean ± SD) Median [min-max]	52.50 ± 53.85 26.00 [1.00–214.30]	31.91 ± 29.01 30.70 [0.50–114.10]	0.241
D-dimer (mean ± SD) Median[min-max]	7.55 ± 5.52 5.52 [0.19–42.30]	1.13 ± 0.99 0.80 [0.10–5.30]	< 0.001

HA headache, DM diabetes mellitus, CAD coronary artery disease, COPD chronic obstructive pulmonary disease