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. 2021 Feb 8;7:4. doi: 10.1038/s41514-021-00056-9

Fig. 5. Model of TCF1-mediated regulation of miR-181a dependent on GSK3ß.

Fig. 5

T cell aging is associated with a loss of miR-181a expression due to reduced TCF1 expression (left). Reduced miR-181a expression contributes to impaired T cell function by activating negative regulatory signaling pathways by miR-181a targets, e.g., ERK dephosphorylation by DUSP6. Inhibition of GSK3ß increases the expression of TCF1 and its target miR-181a in T cells from old adults, thus enhancing downstream T cell activation and proliferation (right).