Fig. 2. Individual protein–protein interaction networks (reticulotypes) for all HCM patients.

The transcriptomic profile of anterior septal myectomy specimens from patients with hypertrophic cardiomyopathy (HCM) (N = 18) was analyzed using a two-step method that included a correlation matrix and protein–protein interaction (PPI) analysis from the consolidated human interactome, as outlined in Fig. 1. The derivative individualized patient networks varied in topology (median = 3629 [2474 min, 5031 max] number of nodes, representing proteins) and complexity (median = 3696 [2014 min, 6626 max] number of edges, representing links or physical protein–protein interactions between nodes), and were used in further analyses informing patient-specific HCM pathophenotypic and clinical parameters.