Table 2.
Node and edge overlap between individual-patient networks for the HCM and DCM cohorts.
| Node overlap | Edge overlap | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DCM1 | DCM2 | DCM3 | DCM4 | DCM5 | DCM6 | DCM1 | DCM2 | DCM3 | DCM4 | DCM5 | DCM6 | |
| HCM1 | 0.48 | 0.47 | 0.51 | 0.65 | 0.56 | 0.62 | 0.03 | 0.02 | 0.03 | 0.04 | 0.03 | 0.04 |
| HCM2 | 0.48 | 0.46 | 0.51 | 0.65 | 0.56 | 0.62 | 0.03 | 0.03 | 0.03 | 0.04 | 0.03 | 0.04 |
| HCM3 | 0.48 | 0.47 | 0.53 | 0.66 | 0.57 | 0.62 | 0.02 | 0.02 | 0.02 | 0.04 | 0.03 | 0.04 |
| HCM4 | 0.49 | 0.47 | 0.52 | 0.65 | 0.57 | 0.61 | 0.02 | 0.02 | 0.02 | 0.04 | 0.03 | 0.03 |
| HCM5 | 0.49 | 0.48 | 0.54 | 0.65 | 0.57 | 0.63 | 0.03 | 0.03 | 0.03 | 0.04 | 0.03 | 0.04 |
| HCM6 | 0.48 | 0.48 | 0.52 | 0.65 | 0.57 | 0.61 | 0.03 | 0.03 | 0.02 | 0.05 | 0.04 | 0.04 |
| HCM7 | 0.47 | 0.46 | 0.51 | 0.64 | 0.55 | 0.60 | 0.02 | 0.02 | 0.03 | 0.04 | 0.03 | 0.03 |
| HCM8 | 0.57 | 0.57 | 0.56 | 0.61 | 0.55 | 0.59 | 0.04 | 0.04 | 0.04 | 0.04 | 0.04 | 0.04 |
| HCM9 | 0.48 | 0.48 | 0.53 | 0.65 | 0.57 | 0.62 | 0.03 | 0.03 | 0.03 | 0.04 | 0.04 | 0.04 |
| HCM10 | 0.48 | 0.47 | 0.52 | 0.65 | 0.57 | 0.63 | 0.03 | 0.02 | 0.03 | 0.04 | 0.04 | 0.04 |
| HCM11 | 0.48 | 0.47 | 0.52 | 0.65 | 0.55 | 0.61 | 0.02 | 0.02 | 0.02 | 0.04 | 0.03 | 0.03 |
| HCM12 | 0.48 | 0.46 | 0.50 | 0.64 | 0.55 | 0.60 | 0.02 | 0.02 | 0.03 | 0.04 | 0.03 | 0.03 |
| HCM13 | 0.57 | 0.57 | 0.54 | 0.61 | 0.55 | 0.58 | 0.04 | 0.04 | 0.04 | 0.04 | 0.04 | 0.04 |
| HCM14 | 0.47 | 0.48 | 0.50 | 0.62 | 0.53 | 0.59 | 0.03 | 0.02 | 0.03 | 0.04 | 0.03 | 0.03 |
| HCM15 | 0.56 | 0.55 | 0.53 | 0.61 | 0.54 | 0.58 | 0.04 | 0.04 | 0.04 | 0.04 | 0.04 | 0.04 |
| HCM16 | 0.46 | 0.46 | 0.49 | 0.63 | 0.54 | 0.59 | 0.02 | 0.02 | 0.03 | 0.05 | 0.03 | 0.04 |
| HCM17 | 0.47 | 0.46 | 0.50 | 0.63 | 0.54 | 0.60 | 0.02 | 0.02 | 0.03 | 0.04 | 0.04 | 0.04 |
| HCM18 | 0.47 | 0.48 | 0.51 | 0.63 | 0.54 | 0.60 | 0.03 | 0.03 | 0.03 | 0.04 | 0.03 | 0.03 |
The transcriptomic profile of anterior septal myectomy specimens from patients with hypertrophic cardiomyopathy (HCM) (N = 18) was analyzed using a two-step method that included a correlation matrix and protein–protein interaction analysis, resulting in individualized patient networks. The same analytical method was used to develop individualized networks for patients with dilated cardiomyopathy (DCM) (N = 6) using a transcriptomic dataset published previously10. Nodes (representing proteins in the networks) and edges (representing links between proteins in the networks) common to individualized patient HCM vs. DCM network pairs are presented. 1, full overlap; 0, no overlap.