Fig. 5. Comparison of the available cryo-EM structures of ex vivo AL amyloid fibrils.

Ribbon diagrams of a λ1 fibril (PDB: 6IC3¹³), the current λ3 fibril (conformation A, PDB: 6Z10), and a λ6 fibril (PDB: 6HUD¹⁴). The fibrils are shown in a cross-sectional view. For all structures, the location of the disulfide bond forming cysteine residues is marked. Disordered segments are represented as dotted gray lines and depicted in an arbitrary conformation. The first and the last residue of the ordered segments, as well as the first and the last residue of the fibril protein are indicated, if known.