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Hepatic niche signals induce monocyte to Kupffer cell differentiation. Following depletion of KCs by diptheria toxin, hepatic stellate cells and liver sinusoidal endothelial cells secrete chemokines and adhesion molecules, recruiting circulating monocytes to the hepatic sinusoid (A). Notch signaling subsequently activates expression of KC LDTFs (B), which in turn establish the Kupffer cell cistrome.
