Table 2.
MCCB scores, miRNA levels, BDNF mRNA, and protein expression levels.
| Schizophrenia | Controls | z or t | p | |
|---|---|---|---|---|
| MCCB | ||||
| Speed of processing | 45.08 (8.53) | 57.67 (7.76) | −8.42 | <0.001 |
| Attention/vigilance | 42.27 (8.74) | 56.77 (11.22) | −8.47 | <0.001 |
| Working memory | 46.73 (9.92) | 57.86 (5.77) | −8.65 | <0.001 |
| Verbal learning and memory | 47.95 (11.20) | 57.00 (7.37) | −5.89 | <0.001 |
| Visual learning and memory | 46.28 (9.12) | 55.05 (6.38) | −6.75 | <0.001 |
| Reasoning and problem solving | 48.40 (10.33) | 57.14 (6.06) | −6.50 | <0.001 |
| Social cognition | 47.32 (9.94) | 54.26 (10.52) | −3.82 | <0.001 |
| Composite score | 45.43 (8.69) | 58.71 (5.85) | −10.74 | <0.001 |
| MiR-195 (2–ΔΔCT) | 2.89 (2.87) | 1.94 (2.13) | −2.59 | 0.010 |
| BDNF mRNA (2–ΔΔCT) | 1.20 (1.41) | 1.97 (2.46) | 4.46 | <0.001 |
| BDNF protein (pg/ml) | 456.46 (191.13) | 545.07 (253.95) | −2.44 | 0.016 |
All data was showed as mean (SD).
MCCB MATRICS Consensus Cognitive Battery, BDNF brain-derived neurotrophic factor.