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. 2021 Feb 8;11:3308. doi: 10.1038/s41598-020-80813-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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FLIM signature of extracellular vesicles (EVs) and the cellular components of their parent cells. (a) Fluorescence lifetime-weighted image of MDA-MB-231 cells with corresponding arrows for nuclei (red), mitochondria (green), and cytosol (cyan). (b) Fluorescence lifetime-weighted image of EVs. Color bar for FLIM images given in ns. (c) Fluorescence lifetime Gaussian fits of major cellular components and EVs. (d) Bar chart showing mean and standard deviation of fluorescence lifetime distributions. *** indicates P < 0.001. (e) Phasor plot showing the phasor components of EVs (blue) and the cellular nuclei (red), mitochondria (green), and cytosol (cyan). Scale bars represent 20 μm.