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. 2021 Feb 8;4:172. doi: 10.1038/s42003-021-01703-3

Fig. 2. IL-36γ is an upstream inflammatory driver in human neutrophils and small airway epithelial cells.

Fig. 2

a, b CXCL1, IL1A, IL1B, and IL36G mRNA expression in human peripheral blood-derived neutrophils (from n = 4 donors) in vitro stimulated with no cytokines (−), IL-36γ, GM-CSF, or IL-36γ+GM-CSF. b IL36R and IL1R mRNA expression in human peripheral blood-derived neutrophils (from n = 4 donors) neutrophils in vitro stimulated with no cytokines (−), IL-36γ, GM-CSF, and IL-36γ+GM-CSF. c, d CXCL1, GM-CSF, and IL1α protein concentrations and CXCL1, IL36G, GM-CSF, IL1A, and IL1B mRNA expression in small airway epithelial cells (SAEC) stimulated with either (−) or IL-36αβγ. a, b *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, vs all other groups by one-way ANOVA and Tukey’s correction. c, d *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001 vs untreated by t test.