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. 2021 Feb 8;4:172. doi: 10.1038/s42003-021-01703-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Relative mRNA amounts of Il36r in naive mouse bone marrow-derived macrophages (BMDMs, n = 6) in response to no stimulation (−) or stimulation with GM-CSF and IL-36γ. b CXCL1 protein concentrations in supernatant of BMDMs (n = 4) after no stimulation (−), or stimulation with IL-36αβγ. IL-1α, IL-1β alone, or in combination with GM-CSF and TGFβ c, d Relative mRNA amounts of Il36g, Cxcl1, Il1a, Il1b, Il1r1, Il1rn, and Il36rn in BMDMs (n = 4) (c) and primary mouse fibroblasts (n = 4) (d) after no stimulation (−) or stimulation with IL-36αβγ, IL-1α, IL-1β alone, or in combination with GM-CSF and TGF-β. e Relative mRNA amounts in primary mouse fibroblasts (n = 4) of Il36r after no stimulation (−) or stimulation with IL-36αβγ or GM-CSF and TGF-β. Shown are the mean values ± SEM of biological replicates. a–d *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001 vs all other groups by one-way ANOVA and Tukey’s correction. e *P ≤ 0.05, vs untreated by t test.