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. 2021 Feb 8;4:172. doi: 10.1038/s42003-021-01703-3

Fig. 4. IL-36γ is an upstream amplifier in human macrophages and fibroblasts.

Fig. 4

a Relative mRNA amounts in human monocyte-derived macrophages (MDM) (depicted are mean values ± SME of technical triplicates from one representative of four experiments) of IL-36G, IL-36R, IL1A, and IL1B and b IL-36γ, IL-36R, IL1A, IL1B, GMCSF, and CXCL1 in primary human lung fibroblasts (n = 4) after no stimulation (−) or stimulation with IL-36αβγ, GM-CSF alone, or with the combination of IL-36αβγ and GM-CSF. Shown are the mean values ± SEM of biological replicates. a, b *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001 vs all other groups by one-way ANOVA and Tukey’s correction.