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. 2021 Feb 8;11:3285. doi: 10.1038/s41598-021-81836-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Functional annotation of 173 single nucleotide polymorphisms (SNPs) found to be in linkage disequilbrium (r² > = 0.6) with the four independent SNPs showing genome-wide significant association with podoconiosis. (A) Distribution of functional consequences of SNPs in genomic risk loci (B) Distribution of combined annotation dependent depletion (CADD) score for SNPs in genomic risk loci. A score greater than 12.37 indicates deleterious SNPs. (C) Distribution of RegulomeDB score for SNPs in genomic risk loci. A score less than 4 indicates regulatory function. (D) Minimum chromatin state for 127 tissue/cell types for SNPs in genomic risk loci. A score less than 7 indicates open chromatin state, indicating higher accessibility.