Figure 1.

(A) Effect of selenium (10 μMol) or of the negative control methylcysteine (MCys) (10 μMol) on Glutathione disulfide (GSSG), released after treatment with H₂O₂ (5 μMol), in fibroblasts from patients with Graves’ orbitopathy (GO fibroblasts) or from control patients. P* and **P = 0.02 vs H₂O₂; ‡ and ‡‡ P = NS vs H₂O₂; P = NS between GO and control fibroblasts; (B) Effect of selenium (10 μMol) or methylcysteine (MCys) (10 μMol) on cell proliferation, induced by H₂O₂ treatment (5 μMol), in GO and control fibroblasts. *P = 0.02 vs untreated cells; **P = 0.02 vs H₂O₂; P = 0.003 between GO and control fibroblasts; (C) Effect of selenium (10 μMol) or methylcysteine (MCys) (10 μMol) on hyaluronic acid (HA) release in GO and control fibroblasts. *P = 0.02 vs H₂O₂; P = 0.02 between Graves’ Orbitopathy and control fibroblasts. Reprinted with permission by Thyroid 2017, Volume 27, pp. 271–278, published by Mary Ann Liebert, Inc., New Rochelle, NY.