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. 2021 Jan 26;10:584280. doi: 10.3389/fonc.2020.584280

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Copyright © 2021 Sharad, Allemang, Li, Nousome, Ku, Whitlock, Sowalsky, Cullen, Sesterhenn, McLeod, Srivastava and Dobi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Graphical Abstract: The overall summary of the findings is presented in the graphical abstract. The age-dependent heterogeneity was found to be associated with tumor differentiation. The activation of oncogenes was found in the young patients whereas loss of tumor suppressors was found in old patents. The uniqueness of the study is the robust enrichment of age-associated prostate tumor gene expression signature achieved by subtraction of normal aging signature of prostate epithelial cells of non-familial prostate cancer patients.