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. 2021 Jan 26;10:584280. doi: 10.3389/fonc.2020.584280

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Copyright © 2021 Sharad, Allemang, Li, Nousome, Ku, Whitlock, Sowalsky, Cullen, Sesterhenn, McLeod, Srivastava and Dobi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Validation of gene expression signatures. Gene profile of old/young age-associated well/poorly differentiated prostate tumors were cross-referenced using RNA-seq gene expression data from recount2 project (A–C) and prostate cancer TCGA cohort (D). The differentially expressed genes (DEGs) of interest were investigated for age (young and old) and Gleason/Differentiation (Well (and Poorly). (A) The gene of interest signature of young poorly differentiated (PD) and well differentiated (WD) tumors; (B) old PD and WD tumors, and (C) the young (42–58 years) and old (66–73 years) are presented in heatmap form. (D) DEGs of interest are presented in the table and heatmap.