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. 2021 Jan 26;11:616141. doi: 10.3389/fimmu.2020.616141

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Copyright © 2021 Hiramatsu-Asano, Sunahori-Watanabe, Zeggar, Katsuyama, Mukai, Morita and Wada

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The decreased level of S1PR1 and increased level of miR-223-3p transcripts in CD4⁺ T cells from SLE patients. (A) mRNA expression of S1PR1 and miR-223-3p in CD4⁺ T cells isolated from healthy (n = 6) and the patients with SLE (n = 15). Data are presented as mean ± SEM. *p < 0.05, ns, not significant, by Wilcoxon signed-rank test. (B, C) The miR-223-3p and S1PR1 transcript level in CD4⁺ T cells isolated from the SLE patients with organ involvement and no involvement. SLE patients with skin involvement (n = 11) and without involvement (n = 4), with lung involvement (n = 2) and without involvement (n = 13), with central nervous system involvement (n = 4) and without involvement (n = 11), with kidney involvement (n = 6) and without involvement (n = 9), with joints involvement (n = 10) and no involvement (n = 5). Data are presented as mean ± SEM. *p < 0.05, ns, not significant, by Student’s t-test.